Vitamin B6 in coenzyme forms performs a wide variety of functions in the body and is extremely versatile, with involvement in more than 100 enzyme reactions, mostly concerned with protein metabolism. Substantial proportions of the naturally occurring pyridoxine in fruits, vegetables, and grains exist in glycosylated forms that exhibit reduced bioavailability. Pyridoxal 5' phosphate (PLP) and pyridoxamine 5' phosphate (PMP) are the active coenzyme forms of vitamin B6. It is the generic name for six compounds (vitamers) with vitamin B6 activity: pyridoxine, an alcohol pyridoxal, an aldehyde and pyridoxamine, which contains an amino group and their respective 5'-phosphate esters. Vitamin B6 is a water-soluble vitamin that is naturally present in many foods, added to others, and available as a dietary supplement. For a general overview of Vitamin B6, see our consumer fact sheet on Vitamin B6. This is a fact sheet intended for health professionals.
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